Therapeutic drug monitoring by reverse Iontophoresis
نویسندگان
چکیده
منابع مشابه
Therapeutic Drug Monitoring By Reverse Iontophoresis
Therapeutic molecules possessing distinct pharmacokinetic variation, narrow therapeutic index and concentration dependent therapeutic/adverse effects demand constant monitoring. The current methods for blood sampling are invasive and possess low patient compliance. Human skin, selective and effective membrane to chemical permeation, offers an alternative route for the extraction of endogenous m...
متن کاملLithium monitoring by reverse iontophoresis in vivo.
BACKGROUND We investigated reverse transdermal iontophoresis as an alternative, noninvasive method for lithium monitoring in vivo. The objectives of such an approach would be to facilitate compliance with treatment and to improve the quality of life for bipolar patients. METHODS We studied 23 bipolar or schizo-affective patients. Over a 2-h period, we extracted lithium and other cations acros...
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Immunosuppressants require therapeutic drug monitoring because of their narrow therapeutic index and significant inter-individual variability in blood concentrations. This variability can be because of factors like drug-nutrient interactions, drug-disease interactions, renal-insufficiency, inflammation and infection, gender, age, polymorphism and liver mass. Drug monitoring is widely practiced ...
متن کاملNon-invasive diagnosis and monitoring of chronic kidney disease by reverse iontophoresis of urea in vivo.
BACKGROUND Reverse iontophoresis uses a small current to extract molecules and ions through the skin. The aim of the study was to determine whether reverse iontophoresis of urea can be used (i) to diagnose and monitor non-invasively chronic kidney disease (CKD), and (ii) to track urea levels closely during a hemodialysis session. METHODS A current of 0.8mA was applied for 2h in 10 healthy vol...
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ژورنال
عنوان ژورنال: Journal of Basic and Clinical Pharmacy
سال: 2012
ISSN: 0976-0105
DOI: 10.4103/0976-0105.103825